This is the final entry in a four - part series previewing the NCAA Tournament from a betting perspective. Read below for against the spread picks and a brief analysis on every first-round game in the West Region. Lines are the best currently available on the chosen side. Check back this weekend for picks on the round of 32 games.

Struggling with who to pick in your 2025 March Madness bracket? Here is a guide to Sporting News' expert NCAA Tournament analysis, including predictions, upsets, Vegas odds and more to help you get that perfect sheet.

Here are three storylines that stood out after the bracket was revealed and sportsbooks put up their Round 1 odds.