Commissioned by Frederik’s mother, Princess Julia of Nassau, to helm an educational short film about the disease with Frederik at its center, director Mei Fa Tan said she was left “inspired” by the prince but also found it “painful to watch” him struggle with his health.

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.

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Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease.

Prince Frederik, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, died at age 22 on March 1 from the rare genetic condition POLG Mitochondrial disease.

P rince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, died in Paris at age 22 on March 1—a day after Rare Disease Day—of a rare genetic disease known as POLG.

Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.

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Frederik de Nassau died on March 1, in Paris, a day after internationally recognized Rare Disease Day, which takes place on the last day of February.